PD-1:PD-L2 TR-FRET Assay Kit | 72012

PD-1:PD-L2 TR-FRET Assay Kit | 72012 | Gentaur US, UK & Europe Disrtribition

Category: Immunotherapy/Assay Kit

Application: Great for screening small molecular inhibitors for drug discovery and HTS applications.

Background: Cell signaling through the PD-1 receptor upon binding the PD-L2 ligand attenuates immune responses and is exploited by both tumors and viruses.

Description: The PD-1:PD-L2 TR-FRET Assay Kit is designed to measure the inhibition of PD-1 binding to PD-L2 in a homogeneous 384 reaction format. Cell signaling through the PD-1 receptor upon binding the PD-L2 ligand attenuates immune responses and is exploited by both tumors and viruses. This FRET-based assay requires no time-consuming washing steps, making it especially suitable for high throughput screening applications. The assay procedure is straightforward and simple; a sample containing europium-labeled (Eu) PD-1, dye-labeled acceptor, biotin-labeled PD-L2, and an inhibitor is incubated for two hours. Then, the fluorescence intensity is measured using a fluorescence reader.

Product Type: Assay Kit

Shippement Condition: -80°C