PD-1 (Mouse) / NFAT - Reporter - Jurkat Recombinant Cell Line | 79762

PD-1 (Mouse) / NFAT - Reporter - Jurkat Recombinant Cell Line | 79762 | Gentaur US, UK & Europe Disrtribition

Category: Immunotherapy/Cell Line

Application: • Screen for inhibitors of mouse PD-1 signaling in a cellular context • Characterize the biological activity of mouse PD-1 and its interactions with ligands

Background: The binding of Programmed Cell Death Protein 1 (PD-1), a receptor expressed on activated T-cells, to its ligands, PD-L1 and PD-L2, negatively regulates immune responses. The PD-1 ligands are found on most cancers, and PD-1:PD-L1/2 interaction inhibits T cell activity and allows cancer cells to escape immune surveillance. The PD-1:PD-L1/2 pathway is also involved in regulating autoimmune responses, making these proteins promising therapeutic targets for a number of cancers, as well as multiple sclerosis, arthritis, lupus, and type I diabetes.

Description: Recombinant Jurkat T cell expressing firefly luciferase gene under the control of NFAT response elements with constitutive expression of mouse PD-1 (Programmed Cell Death 1, PDCD1, SLEB2, CD279, GenBank Accession #NM_008798).

Product Type: Cell Line

Shippement Condition: -80°C