Description
PD-1/CD279 Polyclonal Antibody | E-AB-70311 | Gentaur US, UK & Europe Disrtribition
Reactivity: Human, Mouse, Rat
Host: Rabbit
Isotype: IgG
Application: WB
Research Area: Cancer, Cell Biology, Immunology
Background: Programmed cell death 1 (PD-1, also known as CD279) is an immunoinhibitory receptor that belongs to the CD28/CTLA-4 subfamily of the Ig superfamily. It is a 288 amino acid (aa) type I transmembrane protein composed of one Ig superfamily domain, a stalk, a transmembrane domain, and an intracellular domain containing an immunoreceptor tyrosine-based inhibitory motif (ITIM) as well as an immunoreceptor tyrosine-based switch motif (ITSM) . PD-1 is expressed during thymic development and is induced in a variety of hematopoietic cells in the periphery by antigen receptor signaling and cytokines . Engagement of PD-1 by its ligands PD-L1 or PD-L2 transduces a signal that inhibits T-cell proliferation, cytokine production, and cytolytic function . It is critical for the regulation of T cell function during immunity and tolerance. Blockade of PD-1 can overcome immune resistance and also has been shown to have antitumor activity . The calculated molecular weight of PD-1 is 32 kDa. It has been reported that PD-1 is heavily glycosylated and migrates with an apparent molecular mass of 47-55 kDa on SDS-PAGE .
Lead Time: 7~10 days
Concentration: 0.75 mg/mL
Storage: Store at -20°C. Avoid freeze / thaw cycles.
Immunogen: KLH conjugated Synthetic peptide corresponding to Mouse PD-1
Buffer: PBS with 0.02% sodium azide, 1% BSA and 50% glycerol, pH7.4
Purification: Affinity purification
Dilution: WB 1:500-1:2000
Conjugation: Unconjugated
Calculated Molecular Weight: 32 kDa
Observed Molecular Weight: 47-55 kDa
Clonality: Polyclonal
