Description
Parthenolide | 27768-1 | Gentaur US, UK & Europe Disrtribition
Category: Deacetylase/Inhibitors / Activators
Application: N/A
Background: Parthenolide is a sesquiterpene lactone, a class of naturally occurring plant terpenoids, and the active principle of feverfew (Chrysanthemum parthenium). Parthenolide has demonstrated anti-inflammatory, antisecretory and spasmolytic activity. Parthenolide has been shown to inhibit the release of various chemical mediators such as Cox-2, TNF-α and IL-1 in LPS-stimulated macrophages and activation of MAP kinase and NFκβ. Recent findings indicate that parthenolide binds to and directly inhibits Iκβ kinase. The compound has also been shown to block the production of thromboxane B2 and leukotriene B4.
Description: Parthenolide specifically inhibits HDAC1 without affecting other class I/II HDACs.
Product Type: Inhibitor
Shippement Condition: Room temp. (continental US) or gel packs
