Description
Parkin Antibody | F49621-0.4ML | Gentaur US, UK & Europe Disrtribition
Family: Primary antibody
Formulation: In 1X PBS, pH 7.4, with 0.09% sodium azide
Format: Purified
Clone: N/A
Host Animal: Rabbit
Clonality: Polyclonal (rabbit origin)
Species Reactivity: Human, Mouse
Application: WB, IF, FACS, IHC, ELISA
Buffer: N/A
Limitation: This Parkin antibody is available for research use only.
Purity: Purified
Description: Parkin possibly plays a role in the regulation of neuron death. Limits the production of reactive oxygen species (ROS). Regulates cyclin-E during neuronal apoptosis. In collaboration with CHPF isoform 2, may enhance cell viability and protect cells from oxidative stress. Independently of its ubiquitin ligase activity, protects from apoptosis by the transcriptional repression of p53/TP53. May protect neurons against alpha synuclein toxicity, proteasomal dysfunction, GPR37 accumulation, and kainate-induced excitotoxicity. May play a role in controlling neurotransmitter trafficking at the presynaptic terminal and in calcium-dependent exocytosis. May represent a tumor suppressor gene. [UniProt]
Immunogen: A portion of amino acids 387-417 from the human protein was used as the immunogen for this Parkin antibody.
Storage: Aliquot the Parkin antibody and store frozen at -20 °C or colder. Avoid repeated freeze-thaw cycles.
