Parathyroid Hormone Antibody / N Terminal | V3645-20UG

Parathyroid Hormone Antibody / N Terminal | V3645-20UG | Gentaur US, UK & Europe Disrtribition

Family: Primary antibody

Formulation: 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide

Format: Purified

Clone: rPTH/911

Host: Mouse

Clonality: Recombinant Mouse Monoclonal

Isotype: Mouse IgG2b, kappa

Species Reactivity: Human

Application: IHC-P

Application Details: Immunohistochemistry (FFPE; not suitable for frozen tissues): 0.5-1ug/ml for 30 min at RT

Application Note: Optimal dilution of the recombinant Parathyroid Hormone antibody should be determined by the researcher.

1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.

Purity: Protein G affinity chromatography

Description: PTH/Parathyroid hormone is a hormone produced by the parathyroid gland that regulates the concentration of calcium and phosphorus in extracellular fluid. This hormone elevates blood Ca2+ levels by dissolving the salts in bone and preventing their renal excretion. It is produced in the parathyroid gland as an 84 amino acid single chain polypeptide. It can also be secreted as N-terminal truncated fragments or C-terminal fragments after intracellular degradation, as in case of hypercalcemia. Defects in this gene are a cause of familial isolated hypoparathyroidism (FIH); also called autosomal dominant hypoparathyroidism or autosomal dominant hypocalcemia. FIH is characterized by hypocalcemia and hyperphosphatemia due to inadequate secretion of parathyroid hormone. Symptoms are seizures, tetany and cramps. FIH exist both as autosomal dominant and recessive forms of hypoparathyroidism.

Immunogen: A synthetic peptide from the N-terminal region of the human protein was used as the immunogen for the recombinant Parathyroid Hormone antibody.

Storage: Store the recombinant Parathyroid Hormone antibody at 2-8oC (with azide) or aliquot and store at -20 °C or colder (without azide).

Localization: Cytoplasmic and secreted