Parathyroid Hormone Antibody / N Terminal | V3375SAF-100UG

Parathyroid Hormone Antibody / N Terminal | V3375SAF-100UG | Gentaur US, UK & Europe Disrtribition

Family: Primary antibody

Formulation: 1 mg/ml in 1X PBS; BSA free, sodium azide free

Format: Purified

Clone: N/A

Host Animal: Rabbit

Clonality: Polyclonal (rabbit origin)

Species Reactivity: Human

Application: IHC-P

Buffer: N/A

Limitation: This PTH antibody is available for research use only.

Purity: Protein A affinity chromatography

Description: PTH/Parathyroid hormone is a hormone produced by the parathyroid gland that regulates the concentration of calcium and phosphorus in extracellular fluid. This hormone elevates blood Ca2+ levels by dissolving the salts in bone and preventing their renal excretion. It is produced in the parathyroid gland as an 84 amino acid single chain polypeptide. It can also be secreted as N-terminal truncated fragments or C-terminal fragments after intracellular degradation, as in case of hypercalcemia. Defects in this gene are a cause of familial isolated hypoparathyroidism (FIH); also called autosomal dominant hypoparathyroidism or autosomal dominant hypocalcemia. FIH is characterized by hypocalcemia and hyperphosphatemia due to inadequate secretion of parathyroid hormone. Symptoms are seizures, tetany and cramps. FIH exist both as autosomal dominant and recessive forms of hypoparathyroidism.

Immunogen: A synthetic peptide from the N-terminal region of human Parathyroid hormone was used as the immunogen for the PTH antibody.

Storage: Store the PTH antibody at 2-8oC (with azide) or aliquot and store at -20 °C or colder (without azide).