Pan-HLA Antibody (MHC II) | V7585-100UG

Pan-HLA Antibody (MHC II) | V7585-100UG | Gentaur US, UK & Europe Disrtribition

Family: Primary antibody

Formulation: 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide

Format: Purified

Clone: HLA-Pan/2967R

Host Animal: Rabbit

Clonality: Monoclonal (mouse origin)

Species Reactivity: Human

Application: ELISA, FACS, IF, WB, IHC-P

Buffer: N/A

Limitation: This Pan-HLA antibody is available for research use only.

Purity: Protein A affinity chromatography

Description: Reacts with a common epitope of human major histocompatibility (MHC) class II antigens, HLA-DP, -DQ and -DR. Human MHC class II antigens are transmembrane glycoproteins composed of an alpha chain (36kDa) and a beta chain (27kDa). They are expressed primarily on antigen presenting cells such as B lymphocytes, monocytes, macrophages, and thymic epithelial cells and are also present on activated T lymphocytes. Human MHC class II genes are located in the HLA-D region that encodes at least six alpha and ten beta chain genes. Three loci, DR, DQ and DP, encode the major expressed products of the human class II region. The human MHC class II molecules bind intracellularly processed peptides and present them to T-helper cells. They, therefore, have a critical role in the initiation of the immune response. It has been shown that some autoimmune diseases are associated with certain class II alleles.

Immunogen: The non-T, non-B human acute lymphoblastic leukemia REH6 cell line was used as the immunogen for the Pan-HLA antibody.

Storage: Store the Pan-HLA antibody at 2-8oC (with azide) or aliquot and store at -20 °C or colder (without azide).