Description
Pan-HLA Antibody MHC II (DP/DQ/DR) | V8840SAF-100UG | Gentaur US, UK & Europe Disrtribition
Family: Primary antibody
Formulation: 1 mg/ml in 1X PBS; BSA free, sodium azide free
Format: Purified
Clone: HLA-Pan/6663
Host Animal: Mouse
Clonality: Monoclonal (mouse origin)
Species Reactivity: Human
Application: FACS, IHC-P
Buffer: N/A
Limitation: This Pan-HLA antibody is available for research use only.
Purity: Protein A/G affinity
Description: Reacts with a common epitope of human major histocompatibility (MHC) class II antigens, HLA-DP, -DQ and -DR. Human MHC class II antigens are transmembrane glycoproteins composed of an alpha chain (36kDa) and a beta chain (27kDa). They are expressed primarily on antigen presenting cells such as B lymphocytes, monocytes, macrophages, and thymic epithelial cells and are also present on activated T lymphocytes. Human MHC class II genes are located in the HLA-D region that encodes at least six alpha and ten beta chain genes. Three loci, DR, DQ and DP, encode the major expressed products of the human class II region. The human MHC class II molecules bind intracellularly processed peptides and present them to T-helper cells. They, therefore, have a critical role in the initiation of the immune response.
Immunogen: Priess human B cell line was used as the immunogen for the Pan-HLA antibody.
Storage: Aliquot the Pan-HLA antibody and store frozen at -20 °C or colder. Avoid repeated freeze-thaw cycles.
