Description
p70S6Kb, GST-tag | 40146 | Gentaur US, UK & Europe Disrtribition
Category: Kinase-Serine/Threonine/Protein
Application: Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling
Background: p70S6Kb is a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases and is activated by mitogenic stimuli, including growth factors, cytokines, and phorbol esters. p70S6Kb contains 2 nonidentical kinase catalytic domains and phosphorylates the S6 ribosomal protein and eucaryotic translation initiation factor 4B. Phosphorylation of S6 leads to an increase in protein synthesis and cell proliferation. PI3 kinase pathway and mTOR are involved in the activation of p70S6Kb but other pathways can also activate this target protein.
Description: Recombinant human p70S6Kb, also known as RPS6KB2, STK14B, KLS, P70-beta, or SRK, GenBank Accession No. BC_000094, fulllength with an N-terminal GST tag and expressed in a baculovirus-infected Sf9 insect cell expression system. MW = 85 kDa.
Product Type: Protein
Shippement Condition: -80°C
