p62 Antibody (SQSTM1) | F48010-0.08ML

p62 Antibody (SQSTM1) | F48010-0.08ML | Gentaur US, UK & Europe Disrtribition

Family: Primary antibody

Formulation: In 1X PBS pH 7.4 with 0.09% sodium azide

Format: Antigen affinity purified

Clone: N/A

Host Animal: Rabbit

Clonality: Polyclonal (rabbit origin)

Species Reactivity: Human, African Green Monkey

Application: WB, IF, IHC, ELISA

Buffer: N/A

Limitation: This p62 antibody is available for research use only.

Purity: Antigen affinity

Description: SQSTM1/p62 is an adapter protein which binds ubiquitin and may regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1. This protein may play a role in titin/TTN downstream signaling in muscle cells, and may also regulate signaling cascades through ubiquitination. This protein is involved in cell differentiation, apoptosis, immune response and regulation of K(+) channels. SQSTM1/p62 also appears to play a role in macroautophagic removal of intracellular protein aggregates. Cellular depletion studies of SQSTM1/p62 have indicated a role for association with LC3 and aggregate proteins in order to facilitate normal formation of the autophagosome.

Immunogen: A portion of amino acids 317-346 from the human protein was used as the immunogen for this p62 antibody.

Storage: Aliquot the p62 antibody and store frozen at -20 °C or colder. Avoid repeated freeze-thaw cycles.