p38 MAPK Antibody / MAPK14 | F54913-0.4ML

p38 MAPK Antibody / MAPK14 | F54913-0.4ML | Gentaur US, UK & Europe Disrtribition

Family: Primary antibody

Formulation: In 1X PBS, pH 7.4, with 0.09% sodium azide

Format: Purified

Clone: N/A

Host Animal: Rabbit

Clonality: Polyclonal (rabbit origin)

Species Reactivity: Human, Mouse, Rat

Application: WB, FACS

Buffer: N/A

Limitation: This p38 MAPK antibody is available for research use only.

Purity: Antigen affinity purified

Description: MAPK14 is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response.

Immunogen: A portion of amino acids 301-330 from the human protein was used as the immunogen for the p38 MAPK antibody.

Storage: Aliquot the p38 MAPK antibody and store frozen at -20 °C or colder. Avoid repeated freeze-thaw cycles.