Description
p27 Polyclonal Antibody | E-AB-70373 | Gentaur US, UK & Europe Disrtribition
Reactivity: Human
Host: Rabbit
Isotype: IgG
Application: IHC
Research Area: Cancer, Cell Biology, Epigenetics and Nuclear Signaling
Background: This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. Mutations in this gene are associated with multiple endocrine neoplasia type IV (MEN4).
Lead Time: 7~10 days
Concentration: 500 μg/mL
Storage: Store at -20°C. Avoid freeze / thaw cycles.
Immunogen: KLH conjugated Synthetic peptide corresponding to Human p27 KIP 1.
Buffer: PBS with 0.02% sodium azide, 1% BSA and 50% glycerol, pH7.4
Purification: Affinity purification
Dilution: IHC 1:300-1:1000
Conjugation: Unconjugated
Calculated Molecular Weight: N/A
Observed Molecular Weight: N/A
Clonality: Polyclonal
