Description
P21 Polyclonal Antibody | E-AB-40097 | Gentaur US, UK & Europe Disrtribition
Reactivity: Human
Host: Rabbit
Isotype: IgG
Application: WB
Research Area: Cell Biology, Epigenetics and Nuclear Signaling, Signal Transduction
Background: May be involved in p53/TP53 mediated inhibition of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex. Inhibits DNA synthesis by DNA polymerase delta by competing with POLD3 for PCNA binding (PubMed:11595739).
Lead Time: 7~10 days
Concentration: 2 mg/mL
Storage: Store at -20°C. Avoid freeze / thaw cycles.
Immunogen: Recombinant Human P21 protein
Buffer: PBS with 0.05% Proclin300 and 50% glycerol, pH7.4.
Purification: Affinity purification
Dilution: WB 1:500-1:1000
Conjugation: Unconjugated
Calculated Molecular Weight: 18 kDa
Observed Molecular Weight: 18 kDa
Clonality: Polyclonal
