P21 Polyclonal Antibody | E-AB-40097

P21 Polyclonal Antibody | E-AB-40097 | Gentaur US, UK & Europe Disrtribition

Reactivity: Human

Host: Rabbit

Isotype: IgG

Application: WB

Research Area: Cell Biology, Epigenetics and Nuclear Signaling, Signal Transduction

Background: May be involved in p53/TP53 mediated inhibition of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex. Inhibits DNA synthesis by DNA polymerase delta by competing with POLD3 for PCNA binding (PubMed:11595739).

Lead Time: 7~10 days

Concentration: 2 mg/mL

Storage: Store at -20°C. Avoid freeze / thaw cycles.

Immunogen: Recombinant Human P21 protein

Buffer: PBS with 0.05% Proclin300 and 50% glycerol, pH7.4.

Purification: Affinity purification

Dilution: WB 1:500-1:1000

Conjugation: Unconjugated

Calculated Molecular Weight: 18 kDa

Observed Molecular Weight: 18 kDa

Clonality: Polyclonal