p21 Antibody | F52199-0.08ML

p21 Antibody | F52199-0.08ML | Gentaur US, UK & Europe Disrtribition

Family: Primary antibody

Formulation: In 1X PBS pH 7.4 with 0.09% sodium azide

Format: Antigen affinity purified

Clone: N/A

Host Animal: Rabbit

Clonality: Polyclonal (rabbit origin)

Species Reactivity: Mouse

Application: WB, ELISA

Buffer: N/A

Limitation: This anti-p21 antibody is available for research use only.

Purity: Antigen affinity

Description: May be the important intermediate by which p53/TP53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex (By similarity).

Immunogen: A portion of amino acids 126-154 from the mouse protein was used as the immunogen for this anti-p21 antibody.

Storage: Aliquot the anti-p21 antibody and store frozen at -20 °C or colder. Avoid repeated freeze-thaw cycles.