p21 Antibody / CDKN1A | V2085-20UG

p21 Antibody / CDKN1A | V2085-20UG | Gentaur US, UK & Europe Disrtribition

Family: Primary antibody

Formulation: 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide

Format: Purified

Clone: WA-1

Host Animal: Mouse

Clonality: Monoclonal (mouse origin)

Species Reactivity: Human, Mouse, Rat

Application: FACS, IF, IHC-P

Buffer: N/A

Limitation: This p21 antibody is available for research use only.

Purity: Protein G affinity chromatography

Description: This antibody recognizes a 21kDa protein, identified as the p21 or p21WAF1 tumor suppressor protein. This antibody is highly specific and shows no cross-reaction with other closely related mitotic inhibitors. p21 is a specific inhibitor of cdk's and a tumor suppressor involved in the pathogenesis of a variety of malignancies. The expression of this gene acts as an inhibitor of the cell cycle during G1 phase and is tightly controlled by the tumor suppressor protein p53. p21 expression is induced by the wild type, but not mutant, p53. Normal cells generally display a rather intense nuclear expression. Loss of p21 expression has been reported in many carcinomas (gastric carcinoma, non-small cell lung carcinoma, thyroid carcinoma).

Immunogen: Human recombinant protein was used as the immunogen for this p21 antibody.

Storage: Store the p21 antibody at 2-8oC (with azide) or aliquot and store at -20 °C or colder (without azide).