p21 Antibody / CDKN1A | F54392-0.4ML

p21 Antibody / CDKN1A | F54392-0.4ML | Gentaur US, UK & Europe Disrtribition

Family: Primary antibody

Formulation: In 1X PBS, pH 7.4, with 0.09% sodium azide

Format: Purified

Clone: N/A

Host Animal: Rabbit

Clonality: Polyclonal (rabbit origin)

Species Reactivity: Human, Mouse

Application: IF, WB, IHC-P

Buffer: N/A

Limitation: This CDKN1A antibody is available for research use only.

Purity: Antigen affinity purified

Description: May be the important intermediate by which p53/TP53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin- dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D- CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex.

Immunogen: A portion of amino acids 133-164 from the human protein was used as the immunogen for the CDKN1A antibody.

Storage: Aliquot the CDKN1A antibody and store frozen at -20 °C or colder. Avoid repeated freeze-thaw cycles.