Description
P005091 | 27767-2 | Gentaur US, UK & Europe Disrtribition
Category: Ubiquitination/Inhibitors / Activators
Application: N/A
Background: USP7, known as herpes-associated-ubiquitin-specificprotease (HAUSP), is a deubiquitylating enzyme that regulates the levels of the oncoprotein HDM2 and its substrate, the tumor suppressor p53. P005091 accelerated the degradation of HDM2, while analogs of the compound induced dose- and time-dependent increases in the protein levels of p53 and p21. P005091 induced apoptosis in numerous cancer cell lines, including both p53+/+ and p53-mutant cancer cell lines. P005091 also downregulated claspin and phosphorylation of the DNA checkpoint kinase Chk1.
Description: P005091 is a selective, potent inhibitor of USP7 deubiquitylating activity.
Product Type: Inhibitor
Shippement Condition: Room temp. (continental US) or gel packs
