P-Glycoprotein (ABCB1) Antibody | F49437-0.08ML

P-Glycoprotein (ABCB1) Antibody | F49437-0.08ML | Gentaur US, UK & Europe Disrtribition

Family: Primary antibody

Formulation: In 1X PBS, pH 7.4, with 0.09% sodium azide

Format: Purified

Clone: N/A

Host Animal: Rabbit

Clonality: Polyclonal (rabbit origin)

Species Reactivity: Human

Application: WB, ELISA

Buffer: N/A

Limitation: This P-Glycoprotein antibody is available for research use only.

Purity: Purified

Description: The membrane-associated ABCB1 protein is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. ABCB1 is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier.

Immunogen: A portion of amino acids 647-677 from the human protein was used as the immunogen for this P-Glycoprotein antibody.

Storage: Aliquot the P-Glycoprotein antibody and store frozen at -20 °C or colder. Avoid repeated freeze-thaw cycles.