Description
Nutlin-3 | 27711 | Gentaur US, UK & Europe Disrtribition
Category: Protease/Inhibitors / Activators
Application: Useful as an MDM2 antagonist, as a p53 activator and as an apoptosis inducer.
Background: N/A
Description: Cis-imidazoline analog that inhibits the interaction between p53 and its negative regulator MDM2 (IC50 = 0.09 µM). It induces the expression of p53-regulated genes and exhibits potent antiproliferative activity in cells with functional p53, but not in cells with mutated p53. Nutlin-3 also inhibits the growth of human tumor xenografts in nude mice by 90% at a dose of 200 mg/kg.
Product Type: Inhibitors/Activators
Shippement Condition: room temp.
