NUDT15 Polyclonal Antibody | E-AB-64940

NUDT15 Polyclonal Antibody | E-AB-64940 | Gentaur US, UK & Europe Disrtribition

Reactivity: Mouse, Rat

Host: Rabbit

Isotype: IgG

Application: WB

Research Area: Epigenetics and Nuclear Signaling

Background: This gene encodes an enzyme that belongs to the Nudix hydrolase superfamily. Members of this superfamily catalyze the hydrolysis of nucleoside diphosphates, including substrates like 8-oxo-dGTP, which are a result of oxidative damage, and can induce base mispairing during DNA replication, causing transversions. The encoded enzyme is a negative regulator of thiopurine activation and toxicity. Mutations in this gene result in poor metabolism of thiopurines, and are associated with thiopurine-induced early leukopenia. Multiple pseudogenes of this gene have been identified.

Lead Time: 7~10 days

Concentration: 1 mg/mL

Storage: Store at -20°C. Avoid freeze / thaw cycles.

Immunogen: Recombinant fusion protein of human NUDT15 (NP_060753.1).

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification: Affinity purification

Dilution: WB 1:500-1:2000

Conjugation: Unconjugated

Calculated Molecular Weight: 18 kDa

Observed Molecular Weight: 19 kDa

Clonality: N/A