Nucleophosmin Antibody / NPM1 | V7607-20UG

Nucleophosmin Antibody / NPM1 | V7607-20UG | Gentaur US, UK & Europe Disrtribition

Family: Primary antibody

Formulation: 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide

Format: Purified

Clone: NLPP1-1

Host Animal: Mouse

Clonality: Monoclonal (mouse origin)

Species Reactivity: Human

Application: IHC-P, WB

Buffer: N/A

Limitation: This NPM antibody is available for research use only.

Purity: Protein G affinity chromatography

Description: The protein encoded by the NPM1 gene is involved in several cellular processes, including centrosome duplication, protein chaperoning, and cell proliferation. The encoded phosphoprotein shuttles between the nucleolus, nucleus, and cytoplasm, chaperoning ribosomal proteins and core histones from the nucleus to the cytoplasm. This protein is also known to sequester the tumor suppressor ARF in the nucleolus, protecting it from degradation until it is needed. Mutations in this gene are associated with acute myeloid leukemia. [RefSeq]

Immunogen: A portion of amino acids 185-287 from the human protein was used as the immunogen for the NPM antibody.

Storage: Store the NPM antibody at 2-8oC (with azide) or aliquot and store at -20 °C or colder (without azide).