Nucleophosmin Antibody (Npm1) | F52273-0.08ML

Nucleophosmin Antibody (Npm1) | F52273-0.08ML | Gentaur US, UK & Europe Disrtribition

Family: Primary antibody

Formulation: In 1X PBS, pH 7.4, with 0.09% sodium azide

Format: Purified

Clone: 1042CT5.2.1

Host Animal: Mouse

Clonality: Monoclonal (mouse origin)

Species Reactivity: Human

Application: IHC, WB, ELISA

Buffer: N/A

Limitation: This Nucleophosmin antibody is available for research use only.

Purity: Purified

Description: Nucleophosmin is involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors p53/TP53 and ARF. Binds ribosome presumably to drive ribosome nuclear export. Associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. Acts as a chaperonin for the core histones H3, H2B and H4. Stimulates APEX1 endonuclease activity on apurinic/apyrimidinic (AP) double-stranded DNA but inhibits APEX1 endonuclease activity on AP single-stranded RNA. May exert a control of APEX1 endonuclease activity within nucleoli devoted to repair AP on rDNA and the removal of oxidized rRNA molecules. In concert with BRCA2, regulates centrosome duplication. Regulates centriole duplication: phosphorylation by PLK2 is able to trigger centriole replication.

Immunogen: Purified His-tagged protein was used to produced this monoclonal Nucleophosmin antibody.

Storage: Aliquot the Nucleophosmin antibody and store frozen at -20 °C or colder. Avoid repeated freeze-thaw cycles.