NOX4 Antibody / NADPH oxidase 4 | V3410SAF-100UG

NOX4 Antibody / NADPH oxidase 4 | V3410SAF-100UG | Gentaur US, UK & Europe Disrtribition

Family: Primary antibody

Formulation: 1 mg/ml in 1X PBS; BSA free, sodium azide free

Format: Purified

Clone: NOX4/1245

Host Animal: Mouse

Clonality: Monoclonal (mouse origin)

Species Reactivity: Human

Application: ELISA, WB

Buffer: N/A

Limitation: This NOX4 antibody is available for research use only.

Purity: Protein G affinity chromatography

Description: The superoxide-generating NADPH oxidase includes a membrane-bound flavocytochrome containing two subunits, gp91-phox and p22-phox, and the cytosolic proteins p47-phox and p67-phox. During activation of the NADPH oxidase, p47-phox and p67-phox migrate to the plasma membrane where they associate with the flavocytochrome, cytochrome b558, to form the active enzyme complex. The p22 and gp91-phox subunits also function as surface O2 sensors that initiate cellular signaling in response to hypoxic conditions. NOX4 is a renal gp91-phox homolog highly expressed at the site of erythropoietin production in the proximal convoluted tubule epithelial cells of the renal cortex. It is also expressed in fetal tissues, placenta, glioblastoma and vascular cells.

Immunogen: Human recombinant protein was used as the immunogen for this NOX4 antibody.

Storage: Store the NOX4 antibody at 2-8oC (with azide) or aliquot and store at -20 °C or colder (without azide).