Description
NOX4 Antibody / NADPH oxidase 4 | RQ4482 | Gentaur US, UK & Europe Disrtribition
Family: Primary antibody
Formulation: Antibody in PBS with 0.02% sodium azide and 50% glycerol
Format: Purified
Clone: E-14
Host: Rabbit
Clonality: Recombinant Rabbit Monoclonal
Isotype: Rabbit IgG
Species Reactivity: Human, Mouse, Rat
Application: WB, IHC-P
Application Details: Western blot: 1:500-1:2000,Immunohistochemisty (FFPE): 1:50-1:200,Immunofluorescence: 1:50-1:200
Application Note: Optimal dilution of the NOX4 antibody should be determined by the researcher.
Purity: Protein A affinity
Description: Constitutive NADPH oxidase which generates superoxide intracellularly upon formation of a complex with CYBA/p22phox. Regulates signaling cascades probably through phosphatases inhibition. May function as an oxygen sensor regulating the KCNK3/TASK-1 potassium channel and HIF1A activity. May regulate insulin signaling cascade. May play a role in apoptosis, bone resorption and lipolysaccharide-mediated activation of NFKB. May produce superoxide in the nucleus and play a role in regulating gene expression upon cell stimulation. Isoform 3 is not functional. Isoform 5 and isoform 6 display reduced activity. [UniProt]
Immunogen: A synthetic peptide from human NOX4 was used as the immunogen for the NOX4 antibody.
Storage: Store the NOX4 antibody at -20 °C.
Localization: Cytoplasm (ER membrane)
