Description
NOX2 Antibody | R30752 | Gentaur US, UK & Europe Disrtribition
Family: Primary antibody
Formulation: 0.5mg/ml if reconstituted with 0.2ml sterile DI water
Format: Antigen affinity purified
Clone: N/A
Host Animal: Rabbit
Clonality: Polyclonal (rabbit origin)
Species Reactivity: Human, Mouse, Rat
Application: WB, IHC-P
Buffer: N/A
Limitation: This NOX2 antibody is available for research use only.
Purity: Antigen affinity
Description: NADPH Oxidase 2, also called p91-PHOX or GP91-1, is an essential component of phagocytic NADPH-oxidase, a membrane-bound enzyme complex that generates large quantities of microbicidal superoxide and other oxidants upon activation. NOX2 assembled on DC phagosomes in a gp91-phox subunit-dependent manner, and reactive oxygen species were produced in a more sustained manner in immature DC phagosomes than in macrophage phagosomes. As a major player in innate immune responses in neutrophils, it is also involved in adaptive immunity through its activity in DCs. In heart cells, physiologic stretch rapidly activates reduced-form NOX2 to produce reactive oxygen species (ROS) in a process dependent on microtubules (X-ROS signaling).
Immunogen: An amino acid sequence from the middle region of human NOX2 (YWLCRDTHAFEWFADLLQ) was used as the immunogen for this NOX2 antibody (100% homologous in human, mouse and rat).
Storage: After reconstitution, the NOX2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20 °C. Avoid repeated freezing and thawing.
