Description
NOTCH3 Antibody | F49506-0.08ML | Gentaur US, UK & Europe Disrtribition
Family: Primary antibody
Formulation: In 1X PBS, pH 7.4, with 0.09% sodium azide
Format: Purified
Clone: N/A
Host Animal: Rabbit
Clonality: Polyclonal (rabbit origin)
Species Reactivity: Human, Mouse
Application: WB, IF, IHC, ELISA
Buffer: N/A
Limitation: This NOTCH3 antibody is available for research use only.
Purity: Purified
Description: NOTCH3 is the third discovered human homologue of the Drosophilia melanogaster type I membrane protein notch. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remains to be determined. Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL).
Immunogen: A portion of amino acids 2291-2321 from the human protein was used as the immunogen for this NOTCH3 antibody.
Storage: Aliquot the NOTCH3 antibody and store frozen at -20 °C or colder. Avoid repeated freeze-thaw cycles.
