NME2 / nm23-H2 / NDPK-B (Suppressor of Metastasis)(CPTC-NME2-2), 1mg/mL Antibody | BNUM2248-50

NME2 / nm23-H2 / NDPK-B (Suppressor of Metastasis)(CPTC-NME2-2), 1mg/mL Antibody | BNUM2248-50| Gentaur Distribution US, UK & Europe

Summary.: The nm23 gene, a potential suppressor of metastasis, was originally identified by differential hybridization between two murine melanoma sub-lines, one with a high and the second with a low metastatic capacity. Highly metastatic sub-lines exhibit much lower levels of nm23 than less metastatic cells. Based on sequence analysis, nm23 appears highly related to nucleotide diphosphate kinases (NDP). In humans, NDP kinases A and B are identical to two isotypes of human nm23 homologs, namely nm23-H1 and H2, respectively. nm23-H2 is identical in sequence to PuF, a transcription factor that binds to nuclease hypersensitive elements at positions 142 to 115 of the human c-Myc promotor. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors. .

Conjugate: Purified, BSA-free.

Storage Buffer: PBS, no BSA, no azide.

Storage Temperature: 35°C to -5°C .

Application: IHC, FFPE (verified)|WB (verified).

Stability: Stable at room temperature or 37°C (98°F) for 7 days.