Description
NLG919 | 27337-2 | Gentaur US, UK & Europe Disrtribition
Category: Inhibitors / Activators/Immunotherapy
Application: N/A
Background: N/A
Description: NLG919 is an orally available potent inhibitor of the indoleamine-2,3- dioxygenase (IDO) pathway, a crucial pathway involved in allergic inflammation that mediates immunosuppressive effects through metabolization of tryptophan to kynurenine. NLG919 affects differentiation and proliferation of T cells by inducing downstream signaling via GCN2, mTOR and AHR, with values of Ki = 7 nM and EC50 = 75 nM. NLG919 is being investigated for the treatment of immunosuppression associated with cancer.
Product Type: Inhibitors/Activators
Shippement Condition: -80°C
