Description
NKX3.1 Antibody | V8801-20UG | Gentaur US, UK & Europe Disrtribition
Family: Primary antibody
Formulation: 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Format: Purified
Clone: rNKX3.1/6620
Host: Mouse
Clonality: Recombinant Mouse Monoclonal
Isotype: Mouse IgG1, kappa
Species Reactivity: Human
Application: ELISA, IHC-P
Application Details: ELISA (For coating order BSA-free format),Immunohistochemistry (FFPE): 1-2ug/ml
Application Note: Optimal dilution of the NKX3.1 antibody should be determined by the researcher.
Purity: Protein A/G affinity
Description: NKX3.1 is a prostate specific gene encoding a transcription factor that plays an important role in normal prostate development and carcinogenesis. It is a prostatic tumor suppressor gene located on chromosome 8p21.2, which frequently undergoes a loss of heterozygosity. NKX3.1 expression is highly restricted in prostate epithelial cells and therefore can be used as a diagnostic biomarker for prostate cancer and other metastatic lesions of prostatic origin. Furthermore, NKX3.1 shows better sensitivity than Prostate Specific Antigen (PSA) for identifying metastatic prostatic adenocarcinoma. This suggests that immunohistochemical staining of NKX3.1, along with other prostate-restricted markers, may be valuable for the definitive determination of prostatic origin in poorly differentiated metastatic carcinomas.
Immunogen: A portion of amino acids 92-224 was used as the immunogen for the NKX3.1 antibody.
Storage: Aliquot the NKX3.1 antibody and store frozen at -20 °C or colder. Avoid repeated freeze-thaw cycles.
Localization: Nuclear
