Description
Nk1.1 Antibody / Cd161c | V8986-100UG | Gentaur US, UK & Europe Disrtribition
Family: Primary antibody
Formulation: 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Format: Purified
Clone: PK136
Host Animal: Mouse
Clonality: Monoclonal (mouse origin)
Species Reactivity: Mouse
Application: FACS
Buffer: N/A
Limitation: This Nk1.1 antibody is available for research use only.
Purity: Protein A/G affinity
Description: NK-1.1 is commonly used as a mouse NK cell marker. It has also been shown to play a role in NK cell activation, IFN- production, and cytotoxic granule release. It is a type II integral membrane glycoprotein with a C-type lectin domain and is encoded by the Klrb1c/NKR-P1C gene. It is predominantly expressed as a disulfide-linked homodimer on NK cells however; it is also expressed on NK-T cells, a rare population of T lymphocytes. NK1.1 is expressed in some mouse strains, including C57BL/6, FVB/N, and NZB, but not AKR, BALB/c, CBA/J, C3H, DBA/1, DBA/2, NOD, SJL, and 129. Expression of NKR-P1C antigen has been correlated with lysis of tumor cells in vitro and rejection of bone marrow allografts in vivo.
Immunogen: Mouse spleen and bone marrow cells enriched for NK-1+ cells were used as the immunogen for the Nk1.1 antibody.
Storage: Aliquot the Nk1.1 antibody and store frozen at -20 °C or colder. Avoid repeated freeze-thaw cycles.
