Description
NGF Receptor Antibody / p75NTR / CD271 | V2763-20UG | Gentaur US, UK & Europe Disrtribition
Family: Primary antibody
Formulation: 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide
Format: Purified
Clone: NGFR5
Host Animal: Mouse
Clonality: Monoclonal (mouse origin)
Species Reactivity: Human
Application: FACS, IF, IHC-P
Buffer: N/A
Limitation: This p75NTR antibody is available for research use only.
Purity: Protein G affinity chromatography
Description: It recognizes a glycoprotein of 75kDa, identified as low affinity Nerve Growth Factor (NGF) Receptor (p75NGFR) or Neurotrophin Receptor (p75NTR). NGF-receptor contains an extracellular domain containing four 40-amino acid repeats with 6 cysteine residues at conserved positions followed by a serine/threonine-rich region, a single transmembrane domain, and a 155-amino acid cytoplasmic domain. The cysteine-rich region contains the nerve growth factor binding domain. NGF is important for the development, differentiation, and survival of variety of neuronal and non-neuronal cells. Its action is mediated by binding two distinct receptors, the high affinity p140 and low affinity p75.
Immunogen: NGFR from A875 melanoma cells was used as the immunogen for the p75NTR antibody. Its epitope has been localized to amino acids 1-160 of the extracellular domain of NGFR/NTR.
Storage: Store the p75NTR antibody at 2-8oC (with azide) or aliquot and store at -20 °C or colder (without azide).
