Description
NCOA1 Antibody / SRC-1 | R30158 | Gentaur US, UK & Europe Disrtribition
Family: Primary antibody
Formulation: 0.5mg/ml if reconstituted with 0.2ml sterile DI water
Format: Antigen affinity purified
Clone: N/A
Host Animal: Rabbit
Clonality: Polyclonal (rabbit origin)
Species Reactivity: Human, Mouse, Rat
Application: WB, IF/ICC, FACS
Buffer: N/A
Limitation: This SRC-1 antibody is available for research use only.
Purity: Antigen affinity
Description: The nuclear receptor coactivator 1 (NCOA1), also known as Src1, is a transcriptional coregulatory protein that contains several nuclear receptor interacting domains and an intrinsic histone acetyltransferase activity. Src is recruited to DNA promotion sites by ligand-activated nuclear receptors. It in turn acylates histones, which makes downsteam DNA more accessible to transcription. Hence, it assists nuclear receptors in the upregulation of DNA expression. It has been found that the protein can enhance the transcriptional activity of ligand-bound PGR but does not alter the basal activity of the target promoter. It also enhances estrogen receptor, glucocorticoid receptor, thyroid hormone receptor, and retinoid X receptor transcriptional activities through their cognate DNA response elements in the presence of hormone. Additionally, Src may play a role as a bridging molecule between nuclear hormone receptors and general transcription factors.
Immunogen: Human partial recombinant protein (AA 614-826) was used as the immunogen for this Src antibody.
Storage: After reconstitution, the SRC-1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20 °C. Avoid repeated freezing and thawing.
