Description
NBR1 Monoclonal Antibody | E-AB-22148 | Gentaur US, UK & Europe Disrtribition
Reactivity: Human, Mouse, Rat
Host: Mouse
Isotype: IgG
Application: IHC-p, IF
Research Area: Cancer, Cell Biology
Background: The protein encoded by this gene was originally identified as an ovarian tumor antigen monitored in ovarian cancer. The encoded protein contains a B-box/coiled-coil motif, which is present in many genes with transformation potential. It functions as a specific autophagy receptor for the selective autophagic degradation of peroxisomes by forming intracellular inclusions with ubiquitylated autophagic substrates. This gene is located on a region of chromosome 17q21.1 that is in close proximity to the BRCA1 tumor suppressor gene. Alternative splicing of this gene results in multiple transcript variants.NBR1 (NBR1, Autophagy Cargo Receptor) is a Protein Coding gene. Diseases associated with NBR1 include Inclusion Body Myositis and Synucleinopathy. Among its related pathways are Mitophagy - animal. GO annotations related to this gene include ubiquitin binding and mitogen-activated protein kinase binding.
Lead Time: 7~10 days
Concentration: 1 mg/mL
Storage: Store at -20°C. Avoid freeze / thaw cycles.
Immunogen: Recombinant Protein of NBR1
Buffer: PBS with 0.02% sodium azide and 50% glycerol pH 7.4.
Purification: Protein A purification
Dilution: IHC 1:50-300, IF 1:50-1:200
Conjugation: Unconjugated
Calculated Molecular Weight: N/A
Observed Molecular Weight: N/A
Clonality: Monoclonal
