Narc1 Antibody / Neural apoptosis-regulated convertase 1 / Pcsk9 | RQ6387

Narc1 Antibody / Neural apoptosis-regulated convertase 1 / Pcsk9 | RQ6387 | Gentaur US, UK & Europe Disrtribition

Family: Primary antibody

Formulation: 0.5mg/ml if reconstituted with 0.2ml sterile DI water

Format: Purified

Clone: N/A

Host Animal: Rabbit

Clonality: Polyclonal (rabbit origin)

Species Reactivity: Mouse, Rat

Application: WB, Direct ELISA

Buffer: Lyophilized from 1X PBS with 2% Trehalose

Limitation: This Narc1 antibody is available for research use only.

Purity: Antigen affinity purified

Description: Proprotein convertase subtilisin/kexin type 9, also known as PCSK9 and NARC1 (Neural apoptosis-regulated convertase 1), is an enzyme that in humans is encoded by the PCSK9 gene. This gene encodes a proprotein convertase belonging to the proteinase K subfamily of the secretory subtilase family. By genomic sequence analysis, PCSK9 was mapped to chromosome 1p32. This gene is a crucial player in the regulation of plasma cholesterol homeostasis. It may prevent the recycling of LDLR from endosomes to the cell surface or direct it to lysosomes for degradation. PCSK9 can induce ubiquitination of LDLR leading to its subsequent degradation. This gene is involved in the disposal of non-acetylated intermediates of BACE1 in the early secretory pathway.

Immunogen: Recombinant mouse protein (amino acids Q182-H560) was used as the immunogen for the Narc1 antibody.

Storage: After reconstitution, the Narc1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20 °C. Avoid repeated freezing and thawing.