Description
NALP3 Antibody (NLRP3) | R31539 | Gentaur US, UK & Europe Disrtribition
Family: Primary antibody
Formulation: 0.5mg/ml if reconstituted with 0.2ml sterile DI water
Format: Antigen affinity purified
Clone: N/A
Host Animal: Rabbit
Clonality: Polyclonal (rabbit origin)
Species Reactivity: Human
Application: WB
Buffer: N/A
Limitation: This NALP3 antibody is available for research use only.
Purity: Antigen affinity
Description: NLR Family, Pyrin domain containing 3, also known as CIAS1, CRYOPYRIN, NALP3 or PYPAF1, is a protein that in humans is encoded by the NLRP3 gene. It is mapped to 1q44. The encoded protein may play a role in the regulation of inflammation and apoptosis. Consistent with an essential role for NALP3 inflammasomes in antifungal immunity, it has been showed that deficient mice are hypersusceptible to C. albicans infection. Activation of the NLRP3 inflammasome in response to virus or to RNA was dependent upon lysosomal maturation and reactive oxygen species production in human cells. The inflammasome senses obesity-associated danger signals and contributes to obesity-induced inflammation and insulin resistance.
Immunogen: Human partial recombinant protein (21-194) was used as the immunogen for this NLRP3 / NALP3 antibody.
Storage: After reconstitution, the NALP3 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20 °C. Avoid repeated freezing and thawing.
