Description
Myosin Light Chain 2 Antibody / MLC2 / MYL2 | F54326-0.05ML | Gentaur US, UK & Europe Disrtribition
Family: Primary antibody
Formulation: In 1X PBS, pH 7.4, with 0.09% sodium azide
Format: Purified
Clone: N/A
Host Animal: Rabbit
Clonality: Polyclonal (rabbit origin)
Species Reactivity: Human, Mouse, Rat
Application: WB, FACS, IHC-P
Buffer: N/A
Limitation: This Myosin Light Chain 2 antibody is available for research use only.
Purity: Antigen affinity purified
Description: Contractile protein that plays a role in heart development and function (By similarity). Following phosphorylation, plays a role in cross-bridge cycling kinetics and cardiac muscle contraction by increasing myosin lever arm stiffness and promoting myosin head diffusion; as a consequence of the increase in maximum contraction force and calcium sensitivity of contraction force. These events altogether slow down myosin kinetics and prolong duty cycle resulting in accumulated myosins being cooperatively recruited to actin binding sites to sustain thin filament activation as a means to fine-tune myofilament calcium sensitivity to force (By similarity). During cardiogenesis plays an early role in cardiac contractility by promoting cardiac myofibril assembly (By similarity). [UniProt]
Immunogen: A portion of amino acids 42-75 from the human protein was used as the immunogen for the Myosin Light Chain 2 antibody.
Storage: Aliquot the Myosin Light Chain 2 antibody and store frozen at -20 °C or colder. Avoid repeated freeze-thaw cycles.
