MuRF3, SUMO-His-tags | 81054

MuRF3, SUMO-His-tags | 81054 | Gentaur US, UK & Europe Disrtribition

Category: Ubiquitination/Ligases (E3)

Application: Useful as an E3 ligase in ubiquitin-conjugating reactions and to analyze upregulation/downregulation of E3 enzymes.

Background: MuRF3 is a RING domain E3 ligase that is involved in the conjugation of ubiquitin to target substrates. MuRF3 has been demonstrated to function with the E2 enzyme UBE2D3 (UbcH5c) in vitro. MuRF3 is also known as TRIM54 (tripartite motif containing 54) containing a RING-finger/B-box/coiled-coil tripartite fold. MuRF3 has been implicated along with MuRF1 as regulators of protein degradation in striated muscle. MuRF3 also plays important roles in maintaining cardiac function after myocardial infarction.

Description: Human MuRF3 recombinant protein (Genbank Accession No. Q9BYV2), full length with N-terminal SUMO (variant 3)- and His-tags, expressed in E. coli.

Product Type: Protein

Shippement Condition: -80°C