MuRF1, SUMO-His-tags | 81052

MuRF1, SUMO-His-tags | 81052 | Gentaur US, UK & Europe Disrtribition

Category: Ubiquitination/Ligases (E3)

Application: Useful as an E3 ligase in ubiquitin-conjugating reactions and to analyze upregulation/downregulation of E3 enzymes.

Background: MuRF1 (Muscle-specific RING-finger protein 1) is an E3 (ubiquitin protein ligase) that is involved in the conjugation of ubiquitin to target substrates along with E1 and E2 enzymes. MuRF1 is also known as TRIM63 (tripartite motif containing 63) containing a RING-finger/B-box/coiled-coil tripartite fold and is a member of the RING-domain E3 family. MuRF1 has been implicated as a component of atrophy-associated accelerated proteolysis. It is upregulated in a number of different models of atrophy and interacts with numerous myofibrillar proteins.

Description: Human MuRF1 recombinant protein (Genbank Accession No. NP_115977), full length with N-terminal SUMO (variant 3) and His-tags, expressed in E. coli.

Product Type: Protein

Shippement Condition: -80°C