MUC5AC Antibody / Mucin 5AC | V8591BTN

MUC5AC Antibody / Mucin 5AC | V8591BTN | Gentaur US, UK & Europe Disrtribition

Family: Primary antibody

Formulation: 1 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide

Format: Biotin Conjugate

Clone: 45M1

Host Animal: Mouse

Clonality: Monoclonal (mouse origin)

Species Reactivity: Human, Mouse, Rat

Application: IHC-P

Buffer: N/A

Limitation: This biotinylated MUC5AC antibody is available for research use only.

Purity: Protein G affinity chromatography

Description: This MAb recognizes the peptide core of gastric mucin M1 (recently identified as Mucin 5AC). Its epitope is located in the C-terminal cysteine rich part of the peptide core of MUC5AC. Its epitope is destroyed by beta-mercaptoethanol but not by periodate treatment. This mucin is present in primary ovarian mucinous cancer but usually absent in colorectal adenocarcinoma, thus showing an expression pattern opposite to MUC2. Together with a panel of antibodies, Anti-MUC5AC may be useful for differential identification of primary mucinous ovarian tumors from colon adenocarcinoma metastatic to the ovary. MUC5AC antibodies may also be useful for identification of intestinal metaplasia as well as in the identification of pancreatic carcinoma and pre-cancerous changes vs. normal pancreas.

Immunogen: An M1 mucin preparation from the fluid of an ovarian mucinous cyst belonging to an O Le(a-b) patient was used as the immunogen for the biotinylated MUC5AC antibody.

Storage: Store the biotinylated MUC5AC antibody at 2-8oC (up to one month) or aliquot and store at -20 °C (longer term).