Description
MUC1 Antibody (Mucin-1) | F40466-0.08ML | Gentaur US, UK & Europe Disrtribition
Family: Primary antibody
Formulation: In 1X PBS, pH 7.4, with 0.09% sodium azide
Format: Antigen affinity purified
Clone: N/A
Host Animal: Rabbit
Clonality: Polyclonal (rabbit origin)
Species Reactivity: Human
Application: WB, ELISA
Buffer: N/A
Limitation: This MUC1 antibody is available for research use only.
Purity: Antigen affinity
Description: The MUC1 alpha subunit has cell adhesive properties. Can act both as an adhesion and an anti-adhesion protein. May provide a protective layer on epithelial cells against bacterial and enzyme attack. The beta subunit contains a C-terminal domain which is involved in cell signaling, through phosphorylations and protein-protein interactions. Modulates signaling in ERK, SRC and NF-kappa-B pathways. In activated T-cells, influences directly or indirectly the Ras/MAPK pathway. Promotes tumor progression. Regulates TP53-mediated transcription and determines cell fate in the genotoxic stress response. Binds, together with KLF4, the PE21 promoter element of TP53 and represses TP53 activity. [UniProt]
Immunogen: A portion of amino acids 1202-1231 from the human protein was used as the immunogen for this MUC1 antibody.
Storage: Aliquot the MUC1 antibody and store frozen at -20 °C or colder. Avoid repeated freeze-thaw cycles.
