Description
MTAP Antibody | V3868SAF-100UG | Gentaur US, UK & Europe Disrtribition
Family: Primary antibody
Formulation: 1 mg/ml in 1X PBS; BSA free, sodium azide free
Format: Purified
Clone: MTAP/1813
Host Animal: Mouse
Clonality: Monoclonal (mouse origin)
Species Reactivity: Human
Application: ELISA, WB, IHC-P
Buffer: N/A
Limitation: This MTAP antibody is available for research use only.
Purity: Protein G affinity chromatography
Description: Recognizes a protein of 31kDa, which is identified as MTAP (5'-deoxy-5'-methylthioadenosine phosphorylase). It catalyzes the reversible phosphorolysis of methylthioadenosine, which is important in polyamine metabolism and for the salvage of adenine and methionine. The gene encoding MTAP is linked to the tumor suppressor gene, p16INK4A. Deficient levels of MTAP can occur in cancers primarily through co-deletion of the MTAP gene and the p16INK4A gene. Cells expressing MTAP and possessing adenine salvage pathway activity may be less susceptible to malignancy due to growth-inhibitory actions of agents (e.g. antifolates), whose mechanism of action, in part, involves this de novo purine pathway.
Immunogen: A portion of amino acids 97-196 from the human protein was used as the immunogen for the MTAP antibody.
Storage: Store the MTAP antibody at 2-8oC (with azide) or aliquot and store at -20 °C or colder (without azide).
