Description
MTA2 Antibody | RQ4796 | Gentaur US, UK & Europe Disrtribition
Family: Primary antibody
Formulation: Antibody in PBS with 0.02% sodium azide and 50% glycerol
Format: Purified
Clone: ACOE-13
Host Animal: Rabbit
Clonality: Rabbit Monoclonal
Species Reactivity: Human
Application: WB
Buffer: N/A
Limitation: This MTA2 antibody is available for research use only.
Purity: Affinity purified
Description: This gene encodes a protein that has been identified as a component of NuRD, a nucleosome remodeling deacetylase complex identified in the nucleus of human cells. It shows a very broad expression pattern and is strongly expressed in many tissues. It may represent one member of a small gene family that encode different but related proteins involved either directly or indirectly in transcriptional regulation. Their indirect effects on transcriptional regulation may include chromatin remodeling. It is closely related to another member of this family, a protein that has been correlated with the metastatic potential of certain carcinomas. These two proteins are so closely related that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. One of the proteins known to be a target protein for this gene product is p53. Deacetylation of p53 is correlated with a loss of growth inhibition in transformed cells supporting a connection between these gene family members and metastasis. [RefSeq]
Immunogen: A synthetic peptide specific to human MTA2 was used as the immunogen for the MTA2 antibody.
Storage: Store the MTA2 antibody at -20 °C.
