Description
MSH2 Antibody | V7964-100UG | Gentaur US, UK & Europe Disrtribition
Family: Primary antibody
Formulation: 0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Format: Purified
Clone: MSH2/2622
Host Animal: Mouse
Clonality: Monoclonal (mouse origin)
Species Reactivity: Human
Application: FACS, IF, WB, IHC-P
Buffer: N/A
Limitation: This MSH2 antibody is available for research use only.
Purity: Protein G affinity chromatography
Description: Mutations in DNA mismatch repair genes are associated with hereditary nonpolyposis colorectal cancer (HNPCC). Initially, inherited mutations in the MSH2 and MLH1 homologs of the bacterial DNA mismatch repair genes MutS and MutL were found at high frequency in HNPCC and were shown to be associated with microsatellite instability. The demonstration that 10 to 45% of pancreatic, gastric, breast, ovarian and small cell lung cancers also display microsatellite instability has been interpreted to suggest that DNA mismatch repair is not restricted to HNPCC tumors but is a common feature in tumor initiation or progression.
Immunogen: A recombinant human partial protein (amino acids 327-427) was used as the immunogen for this MSH2 antibody.
Storage: Store the MSH2 antibody at 2-8oC (with azide) or aliquot and store at -20 °C or colder (without azide).
