Mouse PD-1[Biotinylated]:PD-L1 Inhibitor Screening Assay Kit | 72027

Mouse PD-1[Biotinylated]:PD-L1 Inhibitor Screening Assay Kit | 72027 | Gentaur US, UK & Europe Disrtribition

Category: Immunotherapy/Assay Kit

Application: This kit is perfect for screening for inhibitors of mouse PD-L1 binding to mouse PD-1.

Background: Cell signaling through the PD-1 receptor upon binding the PD-L1 ligand attenuates immune responses and is exploited by both tumors and viruses for immune evasion.

Description: The Mouse PD-1[Biotinylated]:PD-L1 Inhibitor Screening Assay Kit is designed for screening and profiling inhibitors of this signaling. The key to this kit is the high sensitivity of detection of biotin-labeled PD-1 by streptavidin-HRP. Only a few simple steps on a microtiter plate are required for the assay. First, mouse PD-L1 is coated on a 96-well plate. Next, mouse PD-1 is incubated with mouse PD-L1 on the plate. Finally, the plate is treated with streptavidin-HRP followed by addition of an HRP substrate to produce chemiluminescence, which can then be measured using a chemiluminescence reader.

Product Type: Assay Kit

Shippement Condition: Dry ice