Description
Mouse PAK3, GST-tag | 40147 | Gentaur US, UK & Europe Disrtribition
Category: Kinase-Serine/Threonine/Protein
Application: Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling
Background: PAK3 is a member of the family of serine/threonine p21-activating kinases that serve as targets for the small GTP binding proteins Cdc42 and RAC (1). The PAK family of proteins have been implicated in a wide range of biological activities and are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. PAK3 seems to be necessary for dendritic development and for the rapid cytoskeletal reorganization in dendritic spines associated with synaptic plasticity. A point mutation in PAK3 gene has been linked to nonsyndromic X-linked mental retardation (2).
Description: Recombinant mouse PAK3, full length, with N-terminal GST-tag, expressed by Sf9 insect cells via a baculovirus expression system.
Product Type: Protein
Shippement Condition: -80°C
