Description
Mouse MMP-8 Protein, His Tag (active enzyme, MALS verified) | MM8-M52H8-50ug| Gentaur Distribution US, UK & Europe
Matrix metalloproteinase-8（MMP-8）also known as neutrophil collagenase and CLG1，is a member of matrix metalloproteinases (MMPs) family，which degrade components of the extracellular matrix (ECM) and play essential roles in various physiological processes as well as pathological processes. MMP-8 may affect the metastatic behavior of breast cancer cells through protection against lymph node metastasis, underlining the importance of anti-target identification in drug development. MMP-8 in the tumor may have a protective effect against lymph node metastasis.
Source: Mouse MMP-8, His Tag (MM8-M52H8) is expressed from human 293 cells (HEK293). It contains AA Phe 21 - Ser 465 (Accession # O70138-1). It needs to be activated by agents such as APMA in vitro to have hydrolytic activity.
Format: Liquid.
Tag: C-10×His.
Expression System: HEK293.
Expression Region: Phe 21 - Ser 465.
Conjugate: Unconjugated.
Molecular Weight: 52.7 Kda.
Characteristics: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 52.7 Kda. The protein migrates as 63-68 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Purity: 95%.
Buffer: 20 mM MES, 150 mM NaCl, pH6.0.
Storage Conditions: -70℃.
Shipping Conditions: Dry ice
