Mouse MCAM / CD146 Protein, His Tag | MCM-M52H3-1mg

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SKU:
716-MCM-M52H3-1mg
Availability:
IN STOCK
Weight:
1.20 KGS
€3,184.00
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Description

Mouse MCAM / CD146 Protein, His Tag | MCM-M52H3-1mg| Gentaur Distribution US, UK & Europe

CD146, also known as the melanoma cell adhesion molecule (MCAM) or cell surface glycoprotein MUC18, is a 113kDa cell adhesion molecule currently used as a marker for endothelial cell lineage. As a member of the Immunoglobulin superfamily, It is expressed on chicken embryonic spleen and thymus, activated human T cells, endothelial progenitors such as angioblasts and mesenchymal stem cells, and strongly expressed on blood vessel endothelium and smooth muscle. CD146 has been demonstrated to appear on a small subset of T and B lymphocytes in the peripheral blood of healthy individuals. The CD146+ T cells display an immunophenotype consistent with effector memory cells and have a distinct gene profile from the CD146- T cells. As a Ca2+ independent cell adhesion molecule involved in heterophilic cell to cell interactions and a surface receptor, CD146 triggers tyrosine phosphorylation of FYN and PTK2 and subsequently induced signal transduction, proteolysis or immune recognition.

Source: Mouse MCAM, His Tag (MCM-M52H3) is expressed from human 293 cells (HEK293). It contains AA Val 24 - Val 563 (Accession # Q8R2Y2-1).

Format: Powder.

Tag: C-10×His.

Expression System: HEK293.

Expression Region: Val 24 - Val 563.

Conjugate: Unconjugated.

Molecular Weight: 61.7 kDa.

Characteristics: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 61.7 kDa. The protein migrates as 70-110 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Purity: 95%.

Buffer: PBS, pH7.4.

Storage Conditions: -20℃.

Shipping Conditions: RT

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Additional Information

Size:
1 mg
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