Mouse KLRG1 Protein, His Tag (MALS & SPR verified) | KL1-M5249-1mg

Mouse KLRG1 Protein, His Tag (MALS & SPR verified) | KL1-M5249-1mg| Gentaur Distribution US, UK & Europe

The co-inhibitory receptor killer-cell lectin like receptor G1 (KLRG1) is specifically expressed on NK cells and activated CD8+ T-cells and has been postulated to be a marker of senescence. KLRG1+ T cells are a major reason of chronic tissue damage in some autoimmune diseases such as systemic lupus erythematosus and rheumatoid arthritis. In tumors, tumor cells which express E-cadherin or N-cadherin bind to KLRG1 and inhibit the antitumor activity of T and NK cells. Thus, KLRG1 acts as an immunocheckpoint inhibitory receptor.

Source: Mouse KLRG1, His Tag (KL1-M5249) is expressed from human 293 cells (HEK293). It contains AA Gln 57 - Tyr 188 (Accession # O88713-1).

Format: Powder.

Tag: N-10×His.

Expression System: HEK293.

Expression Region: Gln 57 - Tyr 188.

Conjugate: Unconjugated.

Molecular Weight: 17.1 kDa.

Characteristics: This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 17.1 kDa. The protein migrates as 24-27 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Purity: 95%.

Buffer: PBS, pH7.4.

Storage Conditions: -20℃.

Shipping Conditions: RT