Mouse JNK1, GST-tag | 40071

Mouse JNK1, GST-tag | 40071 | Gentaur US, UK & Europe Disrtribition

Category: Kinase-Serine/Threonine/Protein

Application: Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling

Background: JNK1 is a member of the MAP kinase group that is activated by dual phosphorylation at thr and tyr residues during exposure to stress such as UV irradiation. JNK1 binds to the c-Jun transactivation domain and phosphorylates it on Ser-63 and Ser-73 (1). JNK1 has been shown to play an important role in disease processes. Activation of JNK1 results in defects in myotube viability and integrity leading to dystrophic myofiber destruction (2). JNK1 activity is also abnormally elevated in obesity and removal of JNK1 results in decreased adiposity and significantly improved insulin sensitivity.

Description: Mouse JNK1 (GenBank Accession No. NM_016700), full length with N-terminal GST-tag, MW=71 kDa, expressed in a Baculovirus infected Sf9 cell expression system. The mouse amino acid sequence of JNK1 is identical to the one of human JNK1.

Product Type: Protein

Shippement Condition: -80°C